Restylane was invented in a Swedish laboratory and first used in the U.S. in 2004. It has been injected 10 million times (worldwide) since then, and remains the leading dermal filler. Restylane is generally used for under-eye hollows, lips and labial folds (lines around the nose and mouth). It can last up to 18 months with a repeat injection at four-and-a-half or nine months.
The Restylane line smooths away facial wrinkles and folds ( Restylane Lyft, Restylane Refyne, Restylane Defyne ), provides subtle lip enhancement (Restylane, Restylane Silk), smooths the lines around the mouth (Restylane Silk), adds lift and volume to the cheeks (Restylane Lyft), and helps reverse the signs of volume loss in the back of the hands (Restylane Lyft).